Screen reader users:
Tab into the tool bar.
Then turn the virtual cursor/buffer off to enable pass-through mode.
For JAWS: Insert + Z.
For NVDA: Caps Lock + Space Bar.
For Window-Eyes: Ctrl + Shift + A.
Right and left arrow keys navigate tool bar controls.
Keyboard shortcuts are also available while in pass-through mode:
Alt Control P for play and pause.
Alt Control S for stop.
Alt control M for mute.
Alt control R doubles size of player.
Alt control T toggles focus between elapsed time and toolbar.
VoiceOver users: Use the Enable Player VoiceOver Access button to make the toolbar button text display and then use the Focus Toolbar button to jump into the toolbar. (VoiceOver with Safari 3, only. Safari 4 beta does not work with toolbar. Disable VoiceOver and use keyboard shortcuts.)
Video description provided: